After a girls' night out, endearingly awkward Deb wakes up in the apartment of the most attractive guy in Portland, Maine. She's thrilled, but she can't remember much of what got her there. Pretty boy Ryan only knows it was a mistake and ushers her out the door... into a full-scale zombie apocalypse. Now, a walk of shame becomes a fight for survival as the mismatched pair discovers that the only thing scarier than trusting someone with your life... is trusting them with your heart.

Bartleby (B.) Gaines is a fun loving slacker who, unfortunately, gets turned down for every college he applied for, much to the chagrin of his overly expectant parents. So, with a little cutting and pasting, he creates the South Harmon Institute of Technology, and lo and behold, he is accepted (along with his friends Rory, Hands, and Glen, whose college plans were also all but dashed). However, his parents want to see the website, the campus, and the dean. So now he has his other friend Sherman (who has been accepted to the prestigious Harmon College) build a web page, they lease out an abandoned psychiatric hospital, and they hire Sherman's uncle Ben to be the dean. Problem solved? Not quite. The web page was done so well, that hundreds of students show up at the front door, all of which were turned down by other colleges. Faced with no choice, Bartleby decides to proceed with turning South Harmon into a real college...

Peter is a composer and a likable sad sack who's devastated when his girlfriend of five years, Sarah Marshall, the star of a cheesy CSI-style crime show, dumps him. He weeps, he rails, he mopes. Finally, his step-brother Brian suggests Hawaii, so Peter heads for a resort on Oahu where, as he's checking in, he sees Sarah and her new beau, Aldous, a polymorphously perverse English rocker. The weeping and moping start again, until Peter is rescued by Rachel, a thoughtful hotel clerk who invites him to a luau and to hang out. Although he constantly runs into Sarah and Aldous, Peter starts to come alive again. Will Sarah realize what she's lost, and what about Rachel?